The Compendium of Kāśyapa 8.8.17

8.8.17

utkarṣeccāvakarṣecca bastīn dravyāṇi vā bhiṣak
kuryādyoge tathotkarṣamapakarṣaṃ tu karmaṇi

the physician should increase or decrease the enemas or the substances. / One should likewise make an increase in yoga, but a reduction in karma;