Anandakanda 1.1.46

1.1.46

<yaugikā doṣāḥ>
viṣaṃ nāgaśca vaṅgaśca yaugikaśca trayaḥ smṛtāḥ /
<doṣāṇāṃ svarūpam>
bhaumaḥ kuṣṭhakaraścāpyo doṣodrekaṃ karoti saḥ //

Poison, lead, and tin are remembered as the three compound defects.
<Nature of the Defects>
The earthy produces leprosy; the watery causes an aggravation of the humors;