The Compendium of Caraka 1.26.13

1.26.13

na tu kevalaṃ guṇaprabhāvādeva dravyāṇi kārmukāṇi bhavanti dravyāṇi hi dravyaprabhāvādguṇaprabhāvāddravyaguṇaprabhāvācca tasmiṃstasmin kāle tattadadhikaraṇamāsādya ṭaṃ tāṃ ca yuktimarthaṃ ca taṃ tamabhipretya yat kurvanti tat karma yena kuvanti tadvīryaṃ yatra kurvanti tadadhikaraṇaṃ yadā kurvanti sa kālaḥ yathā kurvanti sa upāyaḥ yat sādhayanti tat phalam //

Substances, however, are not active solely through the specific potency of their qualities; for substances act through the specific potency of the substance, through the specific potency of the qualities, and through the specific potency of both substance and qualities. What they do at that particular time, having reached that particular substrate, and keeping in view that particular application and that particular purpose, that is the action; that by which they do it is the potency; that where they do it is the substrate; when they do it is the time; how they do it is the means; and what they accomplish is the result.