The Compendium of Caraka 1.26.81

1.26.81

tamuvāca bhagavānātreyaḥ dehadhātupratyanīkabhūtāni dravyāṇi dehadhātubhirvirodhamāpadyante parasparaguṇaviruddhāni kānicit kānicit saṃyogāt saṃskārādaparāṇi deśakālamātrādibhiścāparāṇi tathā svabhāvādaparāṇi //

The venerable Ātreya said to him: 'Substances that are hostile to the bodily tissues enter into conflict with those bodily tissues: some through mutually incompatible qualities, some through combination, others through processing, others through place, time, dose, and the like, and others through their inherent nature.'