The Compendium of Caraka 2.5.11

2.5.11

asyāṃ caivāvasthāyāmupadravāḥ kuṣṭhinaṃ spṛśanti; tadyathā---prasravaṇamaṅgabhedaḥ patanānyaṅgāvayavānāṃ tṛṣṇājvarātīsāradāhadaurbalyārocakāvipākāśca, tathāvidhamasādhyaṃ vidyāditi//

And in this very stage, complications afflict the patient with kuṣṭha; that is to say: discharge, cracking of the limbs, falling off of bodily components, thirst, fever, diarrhoea, burning, weakness, anorexia, and indigestion; one should know [a condition] of that kind to be incurable.