The Compendium of Caraka 2.6.16

2.6.16

durbalaṃ tvatikṣīṇabalamāṃsaśoṇitamalpaliṅgamajātāriṣṭamapi bahuliṅgaṃ jātāriṣṭaṃ ca vidyāt, asahatvāhvyādhyauṣadhabalasya; taṃ parivarjayet, kṣaṇenaiva hi prādurbhavantyariṣṭāni, animittaścāriṣṭaprādurbhāva iti//

A weak person, however, whose strength, flesh, and blood are excessively depleted, even if he has few symptoms and fatal signs have not appeared, should be known as having many symptoms and as one in whom fatal signs have appeared, because he cannot withstand the strength of the disease and medicine; one should reject him, for fatal signs manifest in an instant, and the appearance of fatal signs is without obvious cause.