The Compendium of Caraka 3.1.17_1

3.1.17_1

ye hyenaṃ grāmanagaranigamajanapadāḥ satatamupayuñjate ta āndhyaṣāṇḍhyakhālityapālityabhājo hṛdayāpakartinaśca bhavanti, tadyathā --- prācyāścīnāśca; tasmāt kṣāraṃ nātyupayuñjīta//

For the villages, towns, cities, and countries that constantly use it become subject to blindness, impotency, baldness, and premature greying, and suffer from cardiac distress; such as the easterners and the Chinese; therefore, one should not use alkali excessively.