The Compendium of Caraka 3.3.36_2

3.3.36_2

na cānabhyastākālamaraṇabhayanivārakāṇāmakālamaraṇabhayamāgacchet prāṇināṃ, vyarthāścārambhakathāprayogabuddhayaḥ syurmaharṣīṇāṃ rasāyanādhikāre, nāpīndro niyatāyuṣaṃ śatruṃ vajreṇābhihanyāt, nāśvināvārtaṃ *bheṣajenopapādayetāṃ, na maharṣayo yatheṣṭamāyustapasā prāpnuyuḥ, na ca viditaveditavyā maharṣayaḥ sasureśāḥ samyak paśyeyurupadeśeyurācareyurvā/

Nor would fear of untimely death come to living beings who have not practiced avertives of fear of untimely death; and the initial plans, treatises, applications, and intentions of the great ṛṣis in the subject of rasāyana would be useless; nor would Indra strike with his thunderbolt an enemy whose lifespan is predetermined; nor would the Aśvins treat an afflicted person with medicine; nor would the great ṛṣis attain lifespan as desired through asceticism; nor would the great ṛṣis, together with the lord of the gods, who know what is to be known, correctly perceive, teach, or practice.