The Compendium of Caraka 3.6.6

3.6.6

tatra khalveṣāṃ dvayānāmapi doṣāṇāṃ trividhaṃ prakopaṇaṃ; tadyathā---asātmyendriyārthasaṃyogaḥ, prajñāparādhaḥ, pariṇāmaśceti//

Now, among them, there is a threefold aggravation of both kinds of doshas; namely: unwholesome contact of the sense faculties with their objects, intellectual blasphemy, and the transformation [of time].