The Compendium of Caraka 4.5.8_1

4.5.8_1

tatra heturutpattikāraṇaṃ, utpattirjanma, vṛddhirāpyāyanam, upaplavo duḥkhāgamaḥ, ṣaḍdhātuvibhāgo viyogaḥ sajīvāpagamaḥ sa prāṇanirodhaḥ sa bhaṅgaḥ sa lokasvabhāvaḥ/ tasya mūlaṃ sarvopaplavānāṃ ca pravṛttiḥ, nivṛttiruparamaḥ/

There, cause is the causal factor of origination; origin is birth; growth is nourishment; calamity is the arrival of pain; dissolution is the separation of the six elements, which is the departure of the living entity, the cessation of breath, destruction, and the nature of the universe. The root of that and of all calamities is initiation; cessation is desistance.