The Compendium of Caraka 5.1.7

5.1.7

tatra lakṣaṇanimittā nāma sā yasyāḥ śarīre lakṣaṇānyeva hetubhūtāni bhavanti daivāt; lakṣaṇāni hi kāniciccharīropanibaddhāni bhavanti, yāni hi tasmiṃstasmin kāle tatrādhiṣṭhānamāsādya tāṃ tāṃ vikṛtimutpādayanti//

Among these, that which has marks as its cause is that for which bodily marks themselves become causes by destiny; for certain marks are bound to the body, which, finding their locus there at such and such a time, produce such and such a pathological alteration.