The Compendium of Caraka 5.1.9_2

5.1.9_2

tatra prakṛtivarṇamardhaśarīre vikṛtivarṇamardhaśarīre, dvāvapi varṇau maryādānibhaktau dṛṣṭvā; yadyevaṃ savyadakṣiṇavibhāgena, yadyevaṃ pūrvapaścimavibhāgena, yadyuttarādharavibhāgena, yadyantarbahirvibhāgena, āturasyāriṣṭamiti vidyāt; evameva varṇabhedo mukhe+&apyanyatra vartamāno maraṇāya bhavati//

In that regard, having observed the constitutional complexion in half of the body and the pathological complexion in the other half of the body, both complexions being divided by a boundary—whether divided by left and right, whether divided by front and back, whether divided by upper and lower, or whether divided by interior and exterior—one should know it to be a fatal sign (ariṣṭa) for the patient; similarly, a difference in complexion occurring in half of the face or elsewhere leads to death.