The Compendium of Caraka 6.28.16

6.28.16

laṅghanaplavanātyadhvavyāyāmātiviceṣṭitaiḥ/
dhātūnāṃ saṃkṣayāccintāśokarogātikarṣaṇāt//

fasting, swimming, walking excessive distances, physical exercise, excessive exertion; / wasting of the dhātus; excessive emaciation from anxiety, grief, and disease;