The Compendium of Caraka 6.3.26

6.3.26

saṃtāpaḥ sārucistṛṣṇā sāṅgamardo hṛdi vyathā/
jvaraprabhāvo, janmādau nidhane ca mahattamaḥ//

Burning heat, anorexia, thirst, body ache, and pain in the chest— / [such is] the specific power of fever, and it is greatest at the beginning of birth and at death.