The Compendium of Caraka 6.3.335

6.3.335

cirakālaparikliṣṭaṃ durbalaṃ &hīnatejasam/
acireṇaiva kālena sa hanti punarāgataḥ//
&`dīnacetasam' iti pā-.
&athavā 'api parīpākaṃ dhātuṣveva kramānmalāḥ/
yānti jvaramakurvantaste tathā 'apyapakurvate//
&`athavā viparīpākaṃ' iti pā-.
dīnatāṃ śvayathuṃ glāniṃ pāṇḍutāṃ nānnakāmatām/
kaṇḍūrutkoṭhapiḍakāḥ kurvantyagniṃ ca te mṛdum//

Afflicted for a long time, weak, and deficient in vitality,
having returned again, it kills him in no long time.
Or, even without producing fever, the impurities gradually undergo maturation
in the tissues themselves, yet even so they cause harm:
they cause dejection, swelling, lassitude, pallor, lack of desire for food,
itching, urticarial eruptions, and pimples, and they make the digestive fire weak.