The Compendium of Caraka 6.4.14

6.4.14

yattridoṣamasādhyaṃ tanmandāgnerativegavat/
vyādhibhiḥ kṣīṇadehasya vṛddhasyānaśnataśca yat//

and that with all three doshas is incurable; as is that in one with dull digestive fire, of excessive violence,
in one whose body is wasted by diseases, in the aged, and in one who does not eat.