The Compendium of Caraka 6.9.22

6.9.22

sarveṣvapi tu khaveṣu yo hastāvudyamya roṣasaṃrambhānniḥśaṅkamanyeṣvātmani vā nipātayet sa hyasādhyo jñeyaḥ; tathā yaḥ sāśrunetro miḍhrapravṛttaraktaḥ kṣatajihvaḥ prasrutanāsikaśchidyamānacarmā 'apratihanyamānavāṇiḥ satataṃ vikūjan &durvarṇastṛṣārtaḥ pūtigandhaśca sa hiṃsārthinonmatto jñeyaḥ; taṃ parivarjayet//

In all these [types of affliction], however, one who raises his hands in violent fury and unhesitatingly strikes them against others or himself should be known as incurable; likewise, one whose eyes are filled with tears, whose urine flows with blood, whose tongue is lacerated, whose nose is running, whose skin is tearing away, whose speech is unrestrained, who constantly groans, is discolored, afflicted with thirst, and has a putrid smell—he should be known as maddened [by a spirit] seeking to kill; him one should avoid.