The Compendium of Caraka 8.10.6

8.10.6

satyapi doṣaharatve kaṭutīkṣṇoṣṇādi bheṣajādānāt/
duḥkhodgārotkleśāhṛdyatvakoṣṭharujā vireke syuḥ//

Even though it removes doṣas, in purgation, owing to taking pungent, sharp, and hot medicine, / there may be distressful eructation, nausea, unpalatability, and abdominal pain.