The Compendium of Caraka 8.6.40

8.6.40

snigdhasvinnasya cātyalpaṃ dīptāgnerjīrṇamauṣadham/
śītairvā stabdhamāme vā doṣānutkliśya nāharet//

And in one unctuated and sudated, whose digestive fire is blazing, a very small dose of medicine that is digested, / or obstructed by cold, or in the presence of āma, does not dislodge and eliminate the doṣas.