The Compendium of Caraka 2.8.4

2.8.4

They manifest quickly in living beings of the following kind; namely: in those whose minds are impaired by rajas and tamas; whose doshas are agitated, irregular, and abundant; who consume articles of food that are contaminated with dirt, corrupted, impure, and unsuitable, according to an improper rule of intake; who also practice improper application of technical procedures; and who perform other irregular physical activities; or, through excessive depletion, the doshas become aggravated in those whose minds are impaired by rajas and tamas, approach the heart—the supreme seat of the inner self—and settle upon it, as well as upon the seats of the sense faculties.