The Compendium of Caraka 1.25.32

1.25.32

evaṃvādinaṃ bhagavantamātreyamagniveśa uvāca kathamiha bhagavan hitāhiānāmāhārajātānāṃ lakṣaṇamanapavādamabhijānīmahe hitasamākhyātānāmāhārajātānāmahitasamākhyātānāṃ ca mātrākālakriyābhūmidehadoṣapuruṣāvasthāntareṣu viparītakāritvamupalabhāmaha iti //

To the blessed Ātreya speaking thus, Agniveśa said: “How, blessed one, do we recognize here the unexceptionable definition of wholesome and unwholesome articles of food, when we observe contrary effects in articles of food designated as wholesome and designated as unwholesome, across differences of measure, time, preparation, habitat, body, doṣa, person, and state?”