The Compendium of Caraka 1.28.7_5

1.28.7_5

sa eva doṣaḥ saṃsṛṣṭayonirviruddhopakramo gambhīrānugataścirasthitaḥ prāṇāyatanasamuttho marmopaghātī kaṣṭatamaḥ kṣiprakāritamaśca saṃpadyate /

That very same dosha becomes most severe and quickest-acting when its source is combined [with others], when treatments for it are contradictory, when it has penetrated deep, has remained long, has arisen in a seat of life, or injures a vital organ.