The Compendium of Caraka 6.26.116

6.26.116

ghrāṇe tathocchvāsagatiṃ nirudhya māṃsāsradoṣādapi cārbudāni/
ghrāṇāt sravedvā śravaṇānmukhādvā pittāktamasraṃ tvapi pūyaraktam//

So also, having obstructed the passage of respiration in the nose, tumors arise from vitiation of muscle and blood; / or from the nose, ears, or mouth, blood smeared with pitta or pus and blood may discharge.