The Compendium of Suśruta 3.4.99

Suśrutasaṃhitā 3.4.99

mahāprakṛtayastvetā rajaḥsattvatamaḥkṛtāḥ// proktā lakṣaṇataḥ samyagbhiṣak tāśca vibhāvayet//