The Compendium of Caraka 2.2.4_1

2.2.4_1

tasmin pramāṇātivṛtte pittaṃ prakupitaṃ &śarīramanusarpadyadeva yakṛtplīhaprabhavāṇāṃ lohitavahānāṃ ca srotasāṃ lohitābhiṣyandagurūṇi mukhānyāsādya &pratirundhyāt &tadeva lohitaṃ dūṣayati//

When that [blood] exceeds its normal measure, the provoked pitta, spreading throughout the body, reaches the orifices of the blood-carrying channels that arise from the liver and spleen—which are heavy due to the congestion of blood—blocks them, and corrupts that very blood.